1,2,5-THIADIAZOLE DERIVATIVES OF INDOLYLALKYL-PYRIMIDINYL-PIPERAZINES AND PHARMACEUTICAL COMPOSITION BASED ON THESE COMPOUNDS Russian patent published in 2001 - IPC

FIELD: synthesis of biologically-active compounds. SUBSTANCE: invention provides novel derivatives of indolylalkyl-pyrimidinyl-piperazines having general formula I , in which R¹, R², R³ and R⁵ are hydrogen atoms; R⁴ is lower alkoxy; R⁶ amino, lower alkylamino, di-loweralkylamino, or lower alkoxy; X is selected from S, SO, and SO₂; Y and Z are nitrogen atoms; m=0,1,2, or 3; and n is integer from 1 to 5. Compounds may be utilized to alleviate vascular-origin headaches. EFFECT: increased choice of vasodilators. 9 cl, 3 dwg, 14 ex