FIELD: chemical industry. SUBSTANCE: present invention describes acryloyl-substituted pyrrole derivatives of formula (I): in which n is integer of 1 to 5, each of R1 and R2,, which may be both the same and different, is hydrogen, halogen, -CN, -NO2,, C1-C4 alkyl or ; R3 is hydrogen, halogen, -CN or -NO2, each R4 is independently hydrogen or C1-C4 alkyl, A is bond, or - NH-Het-Co- in which Het is saturated or unsaturated pentaatomic or hexaatomic heteromonocyclic ring, and in which 1,2 or 3, R5 is C1-C4 alkyl, and pharmaceutically acceptable salts thereof. Compounds are used as antineoplastic agents. EFFECT: improved properties of the title compounds. 7 cl
Title |
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Author |
Number |
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- Dzhovanni B'Jasoli[It]
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- Marina Chomei[It]
|
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|
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|
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- Khirojuki Kojke[Jp]
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- Ivo Monkovich[Ca]
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|
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|
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|
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- Magasi Khasegava[Jp]
- Suiti Ekokhama[Jp]
|
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- Stefania Stefanelli[It]
- Antonio Suarato[It]
|
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