ACRYLOYL-SUBSTITUTED PYRROLE DERIVATIVES AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PHARMACEUTICAL COMPOSITION BASED THEREON, AND METHOD OF PREPARATION THEREOF Russian patent published in 1997 - IPC

Abstract RU 2094430 C1

FIELD: chemical industry. SUBSTANCE: present invention describes acryloyl-substituted pyrrole derivatives of formula (I): in which n is integer of 1 to 5, each of R1 and R2,, which may be both the same and different, is hydrogen, halogen, -CN, -NO2,, C1-C4 alkyl or ; R3 is hydrogen, halogen, -CN or -NO2, each R4 is independently hydrogen or C1-C4 alkyl, A is bond, or - NH-Het-Co- in which Het is saturated or unsaturated pentaatomic or hexaatomic heteromonocyclic ring, and in which 1,2 or 3, R5 is C1-C4 alkyl, and pharmaceutically acceptable salts thereof. Compounds are used as antineoplastic agents. EFFECT: improved properties of the title compounds. 7 cl

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RU 2 094 430 C1

Authors

Nikola Mongelli[It]

Dzhovanni B'Jasoli[It]

Laura Kapolongo[It]

Gabriehlla Petstsoni[It]

Dates

1997-10-27Published

1990-03-22Filed