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2 194 755

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IPC

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Application

2001106247/13, 2001-03-05

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Start date

2001-03-05

(22)

Actual filing date

2001-03-05

(45)

Published

2002-12-20

(72)

Inventor

Kachko A.V.Ternovoj V.A.Kiselev N.N.Sorokin A.V.Svjatchenko V.A.Netesov S.V.Kiselev S.L.

(73)

Holder

Gosudarstvennyj Nauchnyj Tsentr Virusologii I Biotekhnologii

RECOMBINANT PLASMID DNA PAD5-F CARRYING OF ADENOVIRUS TYPE 5 GENOME FRAGMENT WITH DELETION IN GENE E1B-55K AND STRAIN OF MUTANT ADENOVIRUS ADE 12 EXHIBITING SELECTIVE ANTITUMOR ACTIVITY Russian patent published in 2002 - IPC

Abstract RU 2194755 C2

FIELD: biotechnology, medicine, oncology, genetic engineering, molecular biology. SUBSTANCE: invention presents recombinant plasmid DNA pAd5-f and mutant strain of human adenovirus Ade 12. Recombinant plasmid DNA carries fragment of genome of adenovirus type 5 with deletion in gene E1B- 55K. Mutant strain of adenovirus obtained by homologous recombination using plasmid pAs5-f exhibits the selective antitumor activity. Strain can be used as a base for the development of effective antitumor preparation. EFFECT: valuable medicinal properties of strain and plasmid. 2 cl, 3 dwg, 2 tbl, 4 ex

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RU 2 194 755 C2

Authors

Kachko A.V.

Ternovoj V.A.

Kiselev N.N.

Sorokin A.V.

Svjatchenko V.A.

Netesov S.V.

Kiselev S.L.

Dates

2002-12-20—Published

2001-03-05—Filed