METHOD OF SYNTHESIS OF BACCATIN-III AND 10-DEACETYLBACCATIN-III ESTERS, ACTIVATED ACIDS AND THEIR DERIVATIVES Russian patent published in 1998 - IPC

FIELD: organic chemistry and technology. SUBSTANCE: method of synthesis of esters of baccatin-III or 10-deacetylbaccatin-III of the formula (I) involves esterification the protected baccatin-III or 10-deacetylbaccatin-III of the formula (II) to ester with activated acid of the formula (III) . In formulas (I), (II) and (III): Ar is phenyl or a) R₁-aroyl radical where aryl moiety is phenyl or radical of the formula R₄-O-CO- where R₄ is linear or branched C_1-8-alkyl; R₂ is H; R₃ is the protected group of functional OH-group; R₂ and R₃ together form oxazolidinyl; G₁ is the protected group for function of hydroxyl-group; G₂ is the protected group for function of hydroxyl-group. Esters of compound of the formula (I) can be used for synthesis of taxane derivatives showing antileukemic and antitumor properties. EFFECT: improved method of synthesis. 19 cl, 5 ex