FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to ester derivatives of hexahydronaphthalene of the general formula (I): 
where R1 means group of the formula (II) 
or (III) 
where R2 - hydrogen atom or group of the formula -OR3;; R3 - hydrogen atom or silyl protective group for hydroxyl; R5 - unsubstituted alkyl or alkyl substituted with aryl, free or substituted aralkyl; W - alkylene, and their pharmaceutically acceptable salts showing capability to inhibit cholesterol synthesis and therefore they can be used for treatment and prophylaxis of hypercholesterolemia and different cardiac diseases. EFFECT: improved method of synthesis, enhanced effectiveness of compounds. 25 cl, 2 dwg, 4 tbl, 189 ex
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