FIELD: chemical technology, organic chemistry. SUBSTANCE: invention describes method of decarboxylation of 2-carboxy-3-[2-(dimethylamino)-ethyl] -N-1H- -indole-5-methane sulfonamide (II) in the presence of the corresponding solvent and suitable catalyst under inert atmosphere and at temperature from 189 to 250 C. Method ensures to obtain 3-[2-(dimethylamino)-ethyl] -N-methyl-1H-ind- -ole-5-methane sulfoneamide (formula I), its salts and solvates showing effectiveness for migraine treatment. EFFECT: improved method of synthesis. 4 cl
| Title |
Year |
Author |
Number |
| METHOD OF SYNTHESIS OF 2-CARBOXY-3-[2-(DIMETHYLAMINO)-ETHYL]- -N-METHYL-1H-INDOLE-5-METHANE SULFONEAMIDE |
1993 |
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|
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1993 |
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1995 |
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- Khuan Karlos Del' Kastillo N'Eto
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1999 |
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| DIPEPTIDE DERIVATIVES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, METHODS OF THEIR SYNTHESIS, ANTIHYPERTENSIVE PHARMACEUTICAL COMPOSITION |
1992 |
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