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2 108 327

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IPC

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Application

93004523/04, 1993-02-16

(22)

Actual filing date

1993-02-16

(45)

Published

1998-04-10

(72)

Inventor

Pere Dal'Mases Barkhoan[Es]Fransisko Markillas Olondris[Es]Ana Bosch Rovira[Es]Khose Marija Kal'Dero Ges[Es]

(73)

Holder

Vita-Invest S.A.Kimika Sintetika, S.A.

METHOD OF SYNTHESIS OF 3-[2-(DIMETHYLAMINO)-ETHYL]-N-METHYL- -1H-INDOLE-5-METHANE SULFONEAMIDE Russian patent published in 1998 - IPC

Abstract RU 2108327 C1

FIELD: chemical technology, organic chemistry. SUBSTANCE: invention describes method of decarboxylation of 2-carboxy-3-[2-(dimethylamino)-ethyl] -N-1H- -indole-5-methane sulfonamide (II) in the presence of the corresponding solvent and suitable catalyst under inert atmosphere and at temperature from 189 to 250 C. Method ensures to obtain 3-[2-(dimethylamino)-ethyl] -N-methyl-1H-ind- -ole-5-methane sulfoneamide (formula I), its salts and solvates showing effectiveness for migraine treatment. EFFECT: improved method of synthesis. 4 cl

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RU 2 108 327 C1

Authors

Pere Dal'Mases Barkhoan[Es]

Fransisko Markillas Olondris[Es]

Ana Bosch Rovira[Es]

Khose Marija Kal'Dero Ges[Es]

Dates

1998-04-10—Published

1993-02-16—Filed