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2 108 326

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IPC

(21) (22)

Application

93004583/04, 1993-02-26

(22)

Actual filing date

1993-02-26

(45)

Published

1998-04-10

(72)

Inventor

Pere Dal'Mases Barkhoan[Es]Fransisko Markillas Olondris[Es]Ana Bosch Rovira[Es]Khose Marija Kal'Dero Ges[Es]

(73)

Holder

Vita-Invest S.A.Kimika Sintetika S.A.

METHOD OF SYNTHESIS OF 2-CARBOXY-3-[2-(DIMETHYLAMINO)-ETHYL]- -N-METHYL-1H-INDOLE-5-METHANE SULFONEAMIDE Russian patent published in 1998 - IPC

Abstract RU 2108326 C1

FIELD: chemical technology, organic chemistry. SUBSTANCE: 2-carboxy-3-[2-(di- -methylamino)-ethyl]-N-methyl-1H-indole-5-methane sulfoneamide is synthesized by interaction of 2-carboalkoxy-3-(2-tosylhydr- -oxyethyl)-N-methyl-1H-indole-5-methane sulfoneamide with dimethylamine alcoholic solution followed by saponification of obtained product. The indicated compound can be used as an intermediate substance for synthesis of 3-[2-(dimethylamino)- -ethyl] -N-methyl-1H-indole-5-methane sulfoneamide showing valuable therapeutical property and using for migraine treatment. EFFECT: improved method of synthesis. 6 cl

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RU 2 108 326 C1

Authors

Pere Dal'Mases Barkhoan[Es]

Fransisko Markillas Olondris[Es]

Ana Bosch Rovira[Es]

Khose Marija Kal'Dero Ges[Es]

Dates

1998-04-10—Published

1993-02-26—Filed