IMIDAZOLIDYLIC MACROLIDE OR ITS ISOMERS, OR ITS PHARMACEUTICALLY ACCEPTABLE SALT, METHODS OF ITS SYNTHESIS AND PHARMACEUTICAL COMPOSITION SHOWING IMMUNOSUPPRESSIVE ACTIVITY Russian patent published in 1998 - IPC

FIELD: organic chemistry, heterocyclic compounds. SUBSTANCE: product: imidazolidylic macrolide of the formula (I): where R¹ - group where: G means NR⁶; R² has values indicated for R¹, H, (C₁-C₁₀)-alkyl; R³ - H, OH; R⁴ - H; R⁵ - methyl, ethyl or propyl; R⁶ - H, (C₁-C₆)-alkyl possibly substituted with phenyl that can be substituted with halogen; R⁷ and R⁸ are taken independently from H, (C₁-C₇)-alkyl, R¹⁴O(CH₂)_m- where R¹⁴- - H or (C₁-C₆)-alkyl; m = 0, 1, 2, 3; groups phenyl--(CH₂)_m- and phenyl group can be substituted with substituents X, Y, Z; A is taken from group involving: (C₁-C₁₀)-alkyl, group where s = 0-6, t = 0-6; Q - H; W - oxygen atom; X, Y and Z are taken independently from group involving: H, (C₁-C₁₀)-alkyl, halogen atom, trifluoromethyl, group R¹⁶O(CH₂)_m- where R¹⁶ - H, (C₁-C₆)-alkyl, hydroxy-(C₂-C₃)-alkyl, -CF₃ and m = 0, 1, 2 or 3; or two of substituents X, Y and Z can be bound each with other and form five-membered saturated ring involving 2 oxygen atoms and 3 carbon atoms; n = 2. Invention proposes also two methods of synthesis of compounds (I) and pharmaceutical composition based on thereof. Synthesized compounds show IMMUNOSUPPRESSIVE activity. EFFECT: improved method of synthesis. 8 cl, 2 tbl