FIELD: medical industry; production of vitamins. SUBSTANCE: commercial-scale method for production of folic acid derivative (6S)-isomers is based on chromatographic separation of mixture consisting of two (6RS)-diastereoiromers on chromatographic column using as separating agent, albumin dissolved in buffer solution having pH=5. Solution of mixture of (6RS)-diastereoisomers has concentration 0.1-10 wt.-%. EFFECT: higher efficiency. 8 cl
| Title |
Year |
Author |
Number |
| β-CRYSTALLINE FORM OF CEPHYRONSIMANSETIL AND METHOD OF PREPARATION THEREOF |
1996 |
- Mauritsio Zenoni
- Mario Leone
- Anzhelo Kattaneo
- Leonardo Marsili
|
RU2155767C2 |
| STABLE CRYSTALLINE 6(S)- OR 6(R)-TETRAHYDROFOLIC ACID, METHODS OF THEIR PREPARING AND PHARMACEUTICAL COMPOSITION |
1995 |
- Gans Rudol'F Mjuller
- Martin Ul'Mann
- Rudol'F Mozer
- Tomas Amman
|
RU2165422C2 |
| STABLE CRYSTALLINE SALTS OF TETRAHYDROFOLIC ACID (VARIANTS), METHOD OF THEIR PREPARING AND PHARMACEUTICAL COMPOSITION |
1996 |
- Mjuller Khans Rudol'F
- Ul'Man Martin
- Mozer Rudol'F
- Amman Tomas
|
RU2187508C2 |
| STABLE AQUEOUS COMPOSITIONS OF CYCLODEXTRIN INCLUSION COMPOUNDS, COMPOUNDS INCLUDING α-,β- or γ- DEXTRIN OR ITS ALKYL- OR HYDROXYALKYL DERIVATIVES AND (6R)-OR (6S)-5,10- METHYLENE TETRAHYDROFOLIC ACID OR ITS SALT, METHOD OF STABILIZING AQUEOUS SOLUTIONS, AND METHOD OR PREPARING STABLE SOLUTIONS |
1993 |
- Khans Rudol'F Mjuller
- Martin Ul'Mann
- Jozef Konti
|
RU2135519C1 |
| METHOD OF SYNTHESIS OF (6S)- OR (6R)-TETRAHYDROFOLIC ACID |
1991 |
- Dr.Gans Rudol'F Mjuller[Ch]
- Martin Ulmann[Ch]
- Esef Konti[Ch]
- Gjunter Mjurdel[De]
|
RU2099340C1 |
| PURIFIED FOLLICLE-STIMULATING HORMONE (FSH), PHARMACEUTICAL COMPOSITION, A COMPONENT OF PHARMACEUTICAL COMPOSITION |
1988 |
- Dzhuzeppe Arpajja[It]
- Serenella Serani[It]
- Antonino Sirna[It]
- Stefano Villa[It]
|
RU2105012C1 |
| CONJUGATES OF ANTHRACYCLINE, METHOD FOR THEIR PRODUCTION AND USING |
1992 |
- Franchesko Andzheluchchi[It]
- Daniehla Rudzheri[It]
- Stefania Stefanelli[It]
- Antonio Suarato[It]
- Laura Bersani[It]
|
RU2107690C1 |
| 5-METHYLTETRAHYDROFOLIC ACID CRYSTALLINE ALKALINE-EARTH SALTS (VARIANTS), METHOD FOR THEIR PREPARING AND COMPOSITION FOR PHARMACEUTICAL AGENTS AND NUTRITION SUPPLEMENTS |
2000 |
- Mjuller Khans Rudol'F
- Mozer Rudol'F
- Ehgger Tomas
|
RU2265605C2 |
| METHODS OF EXTRACTION AND CLEANING OF THE HIGH-MOLECULAR DIAMOND-LIKES AND THE COMPOSITIONS CONTAINING SUCH DIAMOND-LIKES |
2002 |
- Dal Dzheremi Eh.
- Karlson Robert M.
|
RU2307822C2 |
| STABLE PHARMACEUTICAL COMPOSITION OF 5,10-METHYLENTETRAHYDROFOLATE |
2004 |
- Mozer Rudol'F
- Ammann Tomas
|
RU2343923C2 |
