FIELD: vitamins, pharmacy. SUBSTANCE: invention relates to crystalline forms of 6(R)- or 6(S)-tetrahydrofolic acid, method of their preparing and pharmaceutical composition. Method involves crystallization of 6(R)-, 6(S)- or 6(RS)-tetrahydrofolic acid in medium of polar solvent. At pH values 3.5 and 2 6(S)-isomer and 6(R)-isomer are obtained. Prepared crystalline compounds exhibit the high degree of purity and extremely high stability to effect of air and increased temperatures without additional additions. Crystalline products can be used for preparing medicinal agents and other derivatives of tetrahydrofolic acid. Invention proposes also pharmaceutical composition containing crystalline products prepared. EFFECT: improved and simplified method of preparing, improved properties. 13 cl, 1 dwg, 7 tbl, 15 ex
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|
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- Blatter Fritts
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