FIELD: organic chemistry. SUBSTANCE: invention relates to a method of synthesis of (6S)- or (6R)-tetrahydrofolic acid or its salts with sulfuric or sulfonic acids. Method involves interaction of (6R,S)-tetrahydrofolic acid with sulfuric or the corresponding sulfonic acid. The obtained salt is subjected for fractional crystallization and if necessary the prepared salts were treated with a base. New salts of (6S)- and (6R)-tetrahydrofolic acid with sulfuric or sulfonic acids were obtained. The synthesized compounds were used in medicine. EFFECT: improved method of synthesis. 10 cl
| Title |
Year |
Author |
Number |
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1996 |
- Mjuller Khans Rudol'F
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- Amman Tomas
|
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1995 |
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- Tomas Amman
|
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1993 |
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|
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2000 |
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|
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1998 |
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| 3-OXY-2-CYCLOBUTNENE-1-ON BASIC SALTS AND METHOD FOR THEIR PRODUCTION |
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1993 |
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