FIELD: organic chemistry, antibiotics. SUBSTANCE: method of acylation of 7-amino group of cephalosporanes provides synthesis of aminothiazolyl-protected adduct of 7-amino-3-acetoxymethyl-3- -cephem-4-carboxylic acid by acylation of indicated amino group with aminothiazolylacetic acid where amino group is protected by phenylacetyl group or phenoxyacetyl group followed by amino group deprotection by an aqueous hydrolysis in the presence of G-amidase or penicillin-$$$-amidase, respectively. Invention describes new N-phenylacetyl-3-substituted cephalosporine also used by indicated method. EFFECT: improved method of synthesis. 3 cl
