FIELD: organophosphorus compounds, pharmacy. SUBSTANCE: invention relates to derivatives of guanidinealkyl-1,1-bis-phosphonic acid as tautomers of the formulas (Ia) 
, (Ib) 
or (Ic) 
where R1,R3,R4,R5,R6 and R7- - hydrogen; R2 - hydrogen, benzimidazole or a group -P(O)--(OR18)2; R18 is C1-5-alkyl; X - hydrogen; R8,R9,R10,R11 is H, C1-5-alkyl; l = 1-4; m = 0 or 1; n = 0-4 being l + m + n = 4 or less except for compound 1-[(aminoiminomethyl)] -methane-1,1- -bis-phosphonic acid tetraethyl ester. Compounds of the formula (I) show effectiveness for treatment and prophylaxis of osteoporosis and insignificant adverse effects. EFFECT: improved method of synthesis, enhanced effectiveness of compounds. 7 cl, 1 tbl, 18 ex
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