FIELD: organic chemistry. SUBSTANCE: products: derivatives of methylene-bis-phosphonic acids of the formula (I) 
where: R1-R4 - hydrogen or (C1-C10)-alkyl and at least one of groups R1-R4 means hydrogen and at least one of these groups does not mean hydrogen; Q1 - hydrogen, hydroxyl; Q2 - the group y-x-(C)nR′R″ where y - free or substituted phenyl or pyridinyl, pyrimidinyl or piperidinyl; x - simple bond, -S- or -NH-group; n = 0-6; R' and R'' - hydrogen or (C1-C4)-alkyl, or their pharmaceutically acceptable salts. Reagent 1: methylene-bis-phosphonic acid tetraester that is hydrolyzed selectively to triester, diester and monoester of methylene-bis-phosphonic acid. Reaction conditions: hydrolysis is carried out with both acid and alkali at 10-150 C. Synthesized compounds were used in medicine for treatment of disorders associated with pyrophosphate function in organism. EFFECT: improved method of synthesis. 4 cl, 1 tbl
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