FIELD: organic chemistry and technology. SUBSTANCE: products: derivatives of bis-phosphonic acid of the formula Q1Q2C[P(O)(OR1)(OR2)] [P(O)(OR3)(OR4)] where one or two groups R1-R4 are CH3, C2H5 or iso-C3H7 and other R1-R4 groups are hydrogen; Q1 - H or OH; Q2 - direct or branched lower alkyl, cycloalkyl, 2-hydroxyethyl, 3-hydroxypropyl, 2-aminoethyl, 3-aminopropyl. Reagent 1: methylene-bis-phosphonic acid tetraether. Reagent 2: acid or base. Reaction conditions: hydrolysis is carried out by steps in an aqueous medium. Synthesized compounds were used in medicine for skeleton system disease treatment. EFFECT: improved method of synthesis. 5 cl, 14 tbl
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