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IPC

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Application

97111749/14, 1997-07-22

(22)

Actual filing date

1997-07-22

(45)

Published

1998-07-20

(72)

Inventor

Markin S.S.Uvarov V.Ju.Sivov I.G.Ljashenko A.A.Semenov M.P.

(73)

Holder

Zakrytoe Aktsionernoe Obshchestvo

RECOMBINANT IMMUNOTOXIN BASED ON DIPHTHERITIC TOXIN AND INTERLEUKIN-2 (DT482-IL2) AND A METHOD OF ITS PREPARING Russian patent published in 1998 - IPC

Abstract RU 2115429 C1

FIELD: medicine. SUBSTANCE: invention relates to the developed recombinant immunotoxin based on DIPHTHERITIC toxin and interleukin-2 where catalytic-transmembrane moiety of diphtheric toxin contains 482 amino acids. Invention proposes also a method of preparing recombinant immunotoxin DT482-IL2. New immunotoxin can be used for making drug used for treatment of tumor and autoimmune diseases. Method provides high protein toxicity and capability to secret into extracellular space. EFFECT: enhanced effectiveness and properties of immunotoxin. 2 cl, 3 dwg

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RU 2 115 429 C1

Authors

Markin S.S.

Uvarov V.Ju.

Sivov I.G.

Ljashenko A.A.

Semenov M.P.

Dates

1998-07-20—Published

1997-07-22—Filed

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