3R,4S 3-[4-(4-FLUOROPHENYL)-4-HYDROXYPIPERIDIN-1- YL)CHROHAN-4,7-DIOL, OPTICAL ISOMERS THEREOF AND PHARMACEUTICAL COMPOSITION BASED THEREON, AND METHOD OF MEDICAL TREATMENT Russian patent published in 1999 - IPC

Abstract RU 2126404 C1

FIELD: medicine. SUBSTANCE: present invention describes neuroprotective 3R*,4S* 3-[4-(4- fluorophenyl)-4-hydroxypiperidin-1-yl)chroman-4,7-diol, enantiomers and pharmaceutically acceptable salts thereof. The present invention describes pharmaceutical compositions based on said compounds. Said salts are effective agents when taken orally for treating diseases or states which are sensitive to treatment with NMDA blocking drugs. The present invention also describes method of blocking NMDA receptor areas. Compound of formula I has activity which is ten times higher than that of the closest prior art. EFFECT: improved properties of the pharmaceutical composition. 10 cl, 4 ex, 1 tbl

Similar patents RU2126404C1

Title Year Author Number
SYNERGETIC TREATMENT OF PARKINSONISM 1995
  • Bertran L. Chenard
  • Frank S. Menniti
RU2176145C2
3-(PIPERIDINYL-1)-CHROMANE-4,7-DIOL AND 1-(4- HYDROXYPHONYL)-2-(PIPERIDINYL-1)ALKANOL DERIVATIVES, PHARMACEUTICAL COMPOSITION AND METHOD OF BINDING NMDA RECEPTOR 1995
  • Bertrand L.Chenard
  • Todd V.Batler
RU2139857C1
BENZOFUSED COMPOUNDS, PHARMACEUTICAL COMPOSITION BASED ON THEREOF, METHOD OF THEIR SYNTHESIS AND A METHOD OF SYNTHESIS OF AN INTERMEDIATE COMPOUND 1992
  • Kevin Koch
RU2114110C1
SUBSTITUTED 3-AMINOQUINUCLIDINES 1992
  • Fumitaka Ito[Jp]
  • Tosikhide Kokura[Jp]
  • Masami Nakane[Jp]
  • Kunio Satake[Jp]
  • Khiroaki Vakabajasi[Jp]
RU2092486C1
BENZOPYRANE AND BENZOCONDENSED COMPOUNDS, INTERMEDIATE COMPOUNDS, PHARMACEUTICAL COMPOSITION AND A METHOD OF INHIBITION 1995
  • Mark A.Dombroski
  • Kevin Kokh
  • Ehntoni Daniehl' Piskop'O
RU2128655C1
N-HYDROXYLUREAS AS ANTI-INFLAMMATORY AGENTS 1995
  • Ando Akemi
  • Stivens Rodni V.
RU2152935C2
SUBSTITUTED N-(INDOLE-2-CARBONYL)-GLYCINEAMIDES AND THEIR DERIVATIVES, METHODS OF TREATMENT OF PATIENTS AND PHARMACEUTICAL COMPOSITION 1996
  • Bernard Khalin
  • Dzhudit Li Tridvej
  • Vill'Jam Kholt Martin
  • Dennis Dzhej Khuver
  • Duglas Fillips
RU2143424C1
PYRROLIDINYL DERIVATIVES OF HYDROXAMIC ACID, METHOD OF PREPARATION THEREOF, INTERMEDIATES, METHOD OF PREPARATION THEREOF (VERSIONS), METHOD OF TREATMENT 1996
  • Fumitaka Ito
RU2144917C1
PIPERIDINE DERIVATIVE 1992
  • Todd V.Batler[Us]
RU2099339C1
HETEROCYCLIC COMPOUND, PHARMACEUTICAL COMPOSITION AND METHOD OF INHIBITION OF 5-LIPOXYGENASE ACTIVITY 1995
  • Rodni V. Stivens
  • Takasi Mano
  • Kazunari Nakao
  • Josijuki Okumura
RU2136666C1

RU 2 126 404 C1

Authors

Todd V.Batler

Bertrand L.Chenard

Dates

1999-02-20Published

1994-11-21Filed