CYCLIC IMINO-DERIVATIVES, THEIR ISOMER MIXTURES, ENANTIOMERS, DIASTEREOMERS OR PHYSIOLOGICALLY TOLERATED SALTS SHOWING ANTITHROMBOTIC ACTION Russian patent published in 1995 - IPC

FIELD: organic chemistry. SUBSTANCE: product: cyclic imino-derivatives of the general formula B-X-A-Y-E where A nonsubstituted or substituted 2-pyrrolidinone or pyrroline-2-one; B nonsubstituted or substituted amino, aminomethyl or amidino-groups; or two nitrogen atoms of amidino-group were bound with ethylene group, cyano, trimethylammonio, guanidino or guanidinomethyl-group; Y-E substituted unbranched C_2-5-alkyl substituents of which can be substituted; X a group of the formula -X₁-X₂-X₃-X₄-X₅-, where X₁ means bond, methylene or ethylene. If methylene is bound with nitrogen atom of A-cycle then between methylene and adjacent residue of X₂ atom of oxygen or sulfur, sulfonyl, imino and other can be occurred; X₂ nonbranched C_2-4-alkylene, C_2-3-alkenylene, and double bond must not adjacent with heteroatom, nonsubstituted or substituted phenylene; X₃ bond or -CO-, -CO-NH- or -NH-CO- if after X₃ no heteroatom or triple bond of B-residue directly; X₄ bond, nonbranched C_1-5-alkylene, nonsubstituted or substituted phenylene; X₂ together with X₃ and X₄ forms nonbranched C_3-7-alkylene, phenanthrenylene or naphthylene, fluorenylene, etc. X₅ bond, or their isomers, enantiomers, diastereomers or physiologically tolerated salts. EFFECT: improved method of synthesis. 1 tbl