METHOD OF RANGE DECREASE OF DAILY DOSES OF PREPARATIONS CONTAINING OXYCODONE, COMPOSITION OF THE CONTROLLED DRUG RELEASE, SOLID MEDICINAL FORM AND TABLET CONTAINING OXYCODONE Russian patent published in 1998 - IPC

FIELD: pharmacy. SUBSTANCE: invention relates to oral pharmaceutical composition exhibiting the controlled drug release. Composition has 10-160 mg oxycodone or its salt and provides mean-maximal oxycodone concentration in plasma in vivo up to 240 ng/ml in 2-4.5 h after administration and mean-minimal concentration of oxycodone in plasma in vivo up to 120 ng/ml in 10-14 h after repeated administration each 12 h at stationary condition. New oral pharmaceutical composition is made as a solid medicinal form and has analgetically effective amount of spheroids, sphere-forming agent and film cover regulating oxycodone or oxycodone salt release at the controlled rate. Solid oral medicinal form as a tablet is preferable. New compositions provide the pain relief in 90% patients at significant dose level decrease. EFFECT: enhanced effectiveness of composition. 11 cl, 5 dwg, 18 tbl, 19 ex