FIELD: medicine, virology, immunology. SUBSTANCE: invention relates to an immunogenic composition able to cause in humans the specific immune response to respiratory-syntytial virus that can be used for administration to the human-host. Invention involves an immunogenic composition able to cause in humans the specific immune response to respiratory-syntytial virus in the host immunized with this composition. The composition is the purified, inactivated RS-virus no containing cellular and serum components but showing noninfectious, nonimmunopotentiating, immunogenic properties and protecting from infection. Virus is cultured on vaccine quality cellular line and collected virus is purified under denaturating conditions to remove cellular and serum components. The purified RS-virus is inactivated with β-propiolactone, nonionic detergent, n-octyl-β-D-gluco-pyranoside and n-octyl-α-D-gluco-pyranoside or ascorbic acid. Immunogenic composition can be used for diagnosis aims also. EFFECT: enhanced immunogenicity. 15 cl, 7 tbl
| Title |
Year |
Author |
Number |
| RESPIRATORY-SYNCYTIAL VIRUS SUBUNIT VACCINE PREPARATION |
1997 |
- Kejts Dzhordzh A.
- Sanuehza Sonja E.
- Oomen Rajmond P.
- Klajn Mishel' Kh.
|
RU2243234C2 |
| HYBRID PROTEIN, HYBRID GENE, METHOD OF PREPARING A HYBRID PROTEIN, VACCINE AGAINST UPPER RESPIRATORY WAY VIRAL DISEASE, BACULOVIRAL EXPRESSION VECTOR (VARIANTS) |
1993 |
- Mishel Kh.Klejn
- Run-Pan Du
- Meri E.Ehvazishin
|
RU2123047C1 |
| POLYVALENT ASSOCIATED DIPHTHERIA, TETANUS TOXOIDS AND PERTUSSIS POLIOVIRUS VACCINES |
1997 |
- Fakhim Raafat E.F.
- Tehn Lehrri Ju.L.
- Barreto L'Juis
- Tippkhavong Dzhon
- Dzhekson Gejl E.D.
|
RU2194531C2 |
| SYNTHETIC HIV PEPTIDE (VARIANTS), IMMUNOGENIC COMPOSITION FOR INDUCTION OF IMMUNE RESPONSE AGAINST HIV PEPTIDES, DIAGNOSTIC SET FOR ASSAY OF HIV-SPECIFIC ANTIBODIES |
1994 |
- Sia Charlz D.I.
- Chong Pele
- Klejn Majkl Kh.
|
RU2201421C2 |
| METHOD OF ISOLATION AND PURIFICATION OF PROTEIN OF MORAXELLA CATARRHALIS EXTERNAL MEMBRANE, STRAIN MORAXELLA CATARRHALIS FOR PREPARING PROTEIN CD, ISOLATED AND PURIFIED NONDENATURATED PROTEIN CD OF MORAXELLA CATARRHALIS EXTERNAL MEMBRANE AND IMMUNOGENIC COMPOSITION COMPRISING PROTEIN CD OF MORAXELLA CATARRHALIS EXTERNAL MEMBRANE |
1995 |
- Jang Jan-Ping
- Khakness Robin E.
- Majers Liza E.
- Makginness Ursula
- Klejn Majkl Kh.
|
RU2186582C2 |
| PURIFIED AND ISOLATED NUCLEIC ACID MOLECULE, RECOMBINANT PLASMID, RECOMBINANT VECTOR, PURIFIED AND ISOLATED PROTEIN, PURIFIED AND ISOLATED PROTEIN D15 OR ITS PART OF EXTERNAL ENVELOPE, SYNTHETIC PEPTIDE, CHIMERIC MOLECULE, IMMUNOGENIC COMPOSITION AND ANTISERUM OR ANTIBODY |
1993 |
- Pele Chong
- Vejn Tomas
- Jan-Ping Jang
- Shina Lusmore
- Du Juan Charlz Sia
- Majkl Klejn
|
RU2141528C1 |
| SYNTHETIC PEPTIDE, SYNTHETIC LIPOPEPTIDE, IMMUNOGENIC CONJUGATE (VARIANTS), METHOD OF OLIGOMER PREPARING, POLYSACCHARIDE PROTECTED BY SOLID POLYETHYLENE GLYCOL MONOMETHYL ESTER |
1993 |
- Pele Chong
- Ali Kandil
- Charl'Z Saja
- Majkl Kh.Klejn
|
RU2141527C1 |
| VACCINE COMPOSITION, METHOD OF IMMUNE SYSTEM STIMULATION |
1993 |
- Brajen Robert Merfi
- Robert Merrit Chenok
- Dzhejms Ehrl Kraueh
- Mark Konnors
- Alan Robert Dehvis
- Majkl Dehvid Ljubek
- Bernard Kh'Ju Selling
|
RU2139729C1 |
| DNA FRAGMENT ENCODING TRANSFERRIN RECEPTOR PROTEIN FRAGMENT OF STRAIN HAEMOPHILUS (VARIANTS), PLASMID VECTOR (VARIANTS), RECOMBINANT PROTEIN (VARIANTS), ISOLATED AND PURIFIED PROTEIN (VARIANTS), IMMUNOGENIC COMPOSITION AND METHOD OF ISOLATION AND PURIFICATION OF PROTEIN |
1994 |
- Luzmor Shina
- Kharkness Robin
- Shriverz Ehntoni
- Chong Pele
- Grej-Ouehn Skott
- Jang Jan-Ping
- Merdin Ehndrju
- Klejn Majkl
|
RU2194757C2 |
| ANALOGUE HIN47 OF HAEMOPHILUS WITH REDUCED PROTEASE ACTIVITY |
1995 |
- Luzmor Shina M.
- Jang Jan-Ping
- Chong Pele
- Oomen Rejmond P.
- Kljajn Mishel' Kh.
|
RU2196176C2 |
