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2 295 570

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(51)

IPC

C12N15/63(2006-01-01)

C12N15/51(2006-01-01)

C12N1/21(2006-01-01)

(21) (22)

Application

2005103702/13, 2005-02-11

(24)

Start date

2005-02-11

(22)

Actual filing date

2005-02-11

(45)

Published

2007-03-20

(72)

Inventor

Veremejko Tat'Jana AleksandrovnaKarpenko Larisa IvanovnaIl'Ichev Aleksandr AlekseevichLebedev Leonid Rudol'FovichZajtsev Boris NikolaevichNekrasova Nadezhda Aleksandrovna

(73)

Holder

Federal'Noe Gosudarstvennoe Uchrezhdenie Nauki Nauchnyj Tsentr Virusologii I Biotekhnologii Federal'Noj Sluzhby Po Nadzoru V Sfere Zashchity Prav Potrebitelej I Blagopoluchija Cheloveka

RECOMBINANT PLASMIDE DNA pU8HBc-preS1, ENCODING PROTEIN GENE OF HEPATITIS B VIRUS CORE ANTIGEN INCLUDING pre-S1 REGION EPITOPE OF HEPATITIS B VIRUS SURFACE PROTEIN AND BACTERIUM STRAIN Escherichia coli AR PRODUCER OF HYBRID HBc-preS1 PROTEIN Russian patent published in 2007 - IPC C12N15/63 C12N15/51 C12N1/21

Abstract RU 2295570 C2

FIELD: microbiological and medicine industry, gene and protein engineering.

SUBSTANCE: disclosed is recombinant plasmide DNA pU8HBc-preS1. Said plasmide encodes chimerical protein gene of hepatitis B virus core antigen bearing pre-S1 region (27-37 a.b.) epitope of hepatitis B virus surface protein. Also disclosed is bacterium strain Escherichia coli DH5αF'/pU8HBc-preS1, bearing of such plasmide and producing hybrid protein HBc-preS1.

EFFECT: invention useful in medicine.

2 cl, 8 dwg, 3 ex

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RU 2 295 570 C2

Authors

Veremejko Tat'Jana Aleksandrovna

Karpenko Larisa Ivanovna

Il'Ichev Aleksandr Alekseevich

Lebedev Leonid Rudol'Fovich

Zajtsev Boris Nikolaevich

Nekrasova Nadezhda Aleksandrovna

Dates

2007-03-20—Published

2005-02-11—Filed