FIELD: chemical industry. SUBSTANCE: invention describes process for preparing 7-trialkylsilyl-baccatin III of general formula I: 
wherein R is C1-4 alkyl optionally substituted by phenyl. The process comprise treating 10-deacetyl-baccatin III of formula II: 
with silylating agent of formula III wherein Hal is Si(R)3 used in 1.5-2.5 moles per mole of original compound at 0-15 C and subsequently treating intermediate 7- trialkylsilyl-10-deacetyl-baccatin III with acetic anhydride. Silylation and acetylation without recovery of intermediate product make it possible to obtain high yield of product I. EFFECT: more efficient preparation process. 8 cl, 1 ex
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|
RU2153496C2 |
| ACID ANHYDRIDES, METHOD OF PREPARATION THEREOF, METHODS OF PREPARATION THEREOF, METHODS OF PREPARATION OF TAXOL OR TAXOTERAN |
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RU2109010C1 |
