FIELD: biotechnology. SUBSTANCE: protein (usually enzyme, preferably hydrolase) in soluble form is converted into form of cross-linked crystal by action with multifunctional cross-linking agent. Cross-linked crystal can be used as base for devices predominantly designed to be applied as biosensors. Cross- linked crystals can also be used in biotechnological synthesis to immobilize enzyme needed for a reaction. EFFECT: prolonged life time of proteins. 40 cl, 12 dwg, 19 tbl, 7 ex
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