STABLE MEDICINAL FORMS EXHIBITING THE SUSTAIN RELEASING AND HAVING ACRYLIC POLYMER COATINGS (VARIANTS) AND A METHOD OF THEIR PRODUCING Russian patent published in 1999 - IPC

FIELD: medicine, pharmacy. SUBSTANCE: method of producing the solid dosed medicinal form for oral use involves preparing a solid substrate containing an active component and an acrylic copolymer an aqueous dispersion, coating a substrate by an aqueous dispersion and obtaining a polymeric coating. Coating provides the sustain releasing an active component. Plasticized mixture consisting of ammonium-methacrylate copolymers that are copolymers of acrylic and methacrylic esters at low content of quaternary ammonium groups is used as an acrylic copolymer. Coating applied on substrate is hardened at temperature above glass transition point of a plasticized mixture of acrylic copolymers for at least 24 h. Obtained solid dosed forms have stable dissolving indices, no alternating at storage at increased temperature and/or increased relative humidity practically. EFFECT: improved method of producing and properties of medicinal forms. 34 cl, 17 tbl, 13 ex