FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to heterocyclic derivatives of azolones of the formula (I)
where Y is CH, N; R1, R2, R3 mean H or C1-4-alkyl; R4, R5 mean H, halogen atom, C1-4-alkyl, C1-4-alkoxy-, hydroxy-group, CF3, OCF3, OCHF2; R6 means pyridinyl possibly substituted with 1-2 alkyls, di-(C1-4-alkyl)-hydroxypyridinyl, di-(C1-4-alkyl)-alkylhydroxypyridinyl, pyridazinyl optionally substituted with C1-4-alkylhydroxy-group, pyrimidinyl optionally substituted with hydroxy- or C1-4-alkoxy-group, thiazolyl optionally substituted with C1-4-alkyl, benzoxazolyl or benzothiazolyl; or R6 means pyrazinyl or pyridazinyl substituted with C1-4-alkyl; Z is C=O or CHOH and
is radical of the formulas (a-1)
, (a-2)
, (a-3)
, (a-4)
, (a-5)
, (a-6)
, (a-7)
. Proposed compounds are powerful agents against microorganism Helicobacter. EFFECT: improved method of synthesis, valuable antibacterial activity. 9 cl, 9 ex
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