HETEROCYCLIC DERIVATIVES OF AZOLONES EFFECTING AGAINST HELICOBACTER, PHARMACEUTICAL COMPOSITION AND METHOD OF THEIR SYNTHESIS Russian patent published in 2000 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to heterocyclic derivatives of azolones of the formula (I) where Y is CH, N; R¹, R², R³ mean H or C_1-4-alkyl; R⁴, R⁵ mean H, halogen atom, C_1-4-alkyl, C_1-4-alkoxy-, hydroxy-group, CF₃, OCF₃, OCHF₂; R⁶ means pyridinyl possibly substituted with 1-2 alkyls, di-(C_1-4-alkyl)-hydroxypyridinyl, di-(C_1-4-alkyl)-alkylhydroxypyridinyl, pyridazinyl optionally substituted with C_1-4-alkylhydroxy-group, pyrimidinyl optionally substituted with hydroxy- or C_1-4-alkoxy-group, thiazolyl optionally substituted with C_1-4-alkyl, benzoxazolyl or benzothiazolyl; or R⁶ means pyrazinyl or pyridazinyl substituted with C_1-4-alkyl; Z is C=O or CHOH and is radical of the formulas (a-1) , (a-2) , (a-3) , (a-4) , (a-5) , (a-6) , (a-7) . Proposed compounds are powerful agents against microorganism Helicobacter. EFFECT: improved method of synthesis, valuable antibacterial activity. 9 cl, 9 ex