FIELD: pharmaceutical chemistry. SUBSTANCE: new biologically active compound, dextravir, containing 10 to 30 wt % of 9-(2-hydroxyethoxymethyl)guanine (acyclovir) is prepared by two methods. In the first one, beta- cyclodextrine and acyclovir are successively dissolved in water or water-alcohol solutions at heating, after which solution of complex formed is concentrated and inclusion compound is isolated. In the second, solid-phase method, dextravir is prepared by mechanically disintegrating acyclovir-beta-cyclodextrine mixture in vibration mill. Principal difference of new inclusion compound from acyclovir is its solubility, which, due to complexing with beta-cyclodextrine, equals 1 g per 280 ml of water. EFFECT: increased solubility. 2 tbl, 4 ex
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