FIELD: organic chemistry, medicine, virology.
SUBSTANCE: invention relates to novel 5'-phosphonates of 3`-azido-3`-deoxythymidine of the general formula (I) possessing anti-HIV activity, and to using 5'-phosphonates of 3`-azido-3`-deoxythymidine as an active component for preparing drugs possessing anti-HIV activity. In compound of the general formula (I): 
at n = 0-2; R1 means 
(wherein X means -CH2, -NH, O); R2 means -NH-C(O)- (wherein R2 means H, (C1-C6)-alkyl, (C5-C7)-cycloalkyl), -HO(CH2)k- (wherein k = 2-4); at n = 0 R1 means -Cl3C; at n = 1-6 R1 means Cl-, Br-, J-, and at n = 2-6 R3 means -C(O)O- (wherein R3 means (C1-C6)-alkyl) at n = 2-6.
EFFECT: valuable medicinal properties of compounds.
3 cl, 2 tbl, 10 ex
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| URETHANE AZT DERIVATIVES - POTENTIAL ANTIVIRAL AGENTS | 2009 |
|
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| METHOD OF PRODUCING 5'-AMINOCARBONYLPHOSPHONATES OF NUCLEOSIDES AND METHOD OF PRODUCING ACYL CHLORIDE OF TRIMETHYLSILYL ETHER OF ETHOXYCARBONYLPHOSPHONIC ACID | 2010 |
|
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| NUCLEOSIDE ANALOG PHOSPHORAMIDATES AS INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPRODUCTION | 2003 |
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| SUBSTITUTED 3'-AZIDO-3'-DEOXYTHYMIDINE 5'-H-PHOSPHONATE AMMONIUM SALT AS SELECTIVE INHIBITORS OF PRODUCTION OF HUMAN IMMUNODEFICIENCY VIRUS HIV-1 AND HIV-2 | 1998 |
|
RU2207343C2 |
| MODIFIED NUCLEOSIDE-5'-TRIPHOSPHATES AS ANTIVIRAL AGENTS | 1996 |
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RU2183213C2 |
| 3'-AZIDO-3'-DEOXYTHYMIDINE 5'-CHOLINE PHOSPHATE AS ANTIVIRAL AGENT | 2002 |
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RU2293739C2 |
| 5'-AMINOCARBONYLPHOPHONATE 3'-AZIDO-3'-DEOXYTHYMIDINE SALTS BEING SELECTIVE INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS HIV-1 | 2010 |
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RU2441016C1 |
