FIELD: medicine, pharmaceutics.
SUBSTANCE: present invention refers to 5'-aminocarbonylphosphonate 3'-azido-3'-deoxythimidine salts showing anti-HIV-1 activity of general formula
where R is an alkaline and alkaline earth metal ion, or an ammonium ion with various substitutes.
EFFECT: preparing new compounds showing the ability to inhibit the human immunodeficiency virus selectively and being stable substances that facilitates preparing based drugs.
1 cl, 12 ex, 1 tbl
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| METHOD OF PRODUCING 5'-AMINOCARBONYLPHOSPHONATES OF NUCLEOSIDES AND METHOD OF PRODUCING ACYL CHLORIDE OF TRIMETHYLSILYL ETHER OF ETHOXYCARBONYLPHOSPHONIC ACID | 2010 |
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| SUBSTITUTED 3'-AZIDO-3'-DEOXYTHYMIDINE 5'-H-PHOSPHONATE AMMONIUM SALT AS SELECTIVE INHIBITORS OF PRODUCTION OF HUMAN IMMUNODEFICIENCY VIRUS HIV-1 AND HIV-2 | 1998 |
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| 5-H-PHOSPHONATE-3-AZIDO-3-DESOXYTTEMIDINE SALTS WHICH ARE SPECIFIC INHIBITORS VICH-1 AND VICH-2 | 1996 |
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| 5'-AMINOCARBONYLPHOSPHONATES D4T AS INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPRODUCTION | 2003 |
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RU2247124C1 |
| DERIVATIVES OF 3'-AZIDO-3'-DEOXYTHYMIDINE 5'-H-PHOSPHONATE AND PHARMACEUTICAL COMPOSITIONS BASED ON THEREOF | 2001 |
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RU2187509C1 |
| MODIFIED 5'-PHOSPHONATES OF 3'-AZIDO-3'-DEOXYTHYMIDINE AS ACTIVE COMPONENTS FOR POTENTIAL ANTIVIRAL PREPARATIONS | 2004 |
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| MODIFIED NUCLEOSIDE-5'-TRIPHOSPHATES AS ANTIVIRAL AGENTS | 1996 |
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| 5'-PHOSPHORUS-CONTAINING DERIVATIVES OF 2',3'-DIDEOXY-3'-THIACYTIDINE - NEW ANTIVIRAL AGENTS | 2007 |
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| FLUORESCENTLY-LABELED DEOXYURIDINE TRIPHOSPHATES | 2016 |
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| 7-METHYL-2'-DEOXYGUANOSINE HYDROIODIDE SALT AS SUBSTRATE FOR PRODUCING 2'-DEOXYNUCLEOSIDES BY METHOD OF ENZYME TRANSGLYCOSYLATION | 2017 |
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