METHOD OF PRODUCING (S)-2-(3-BENZOYLPHENYL)-PROPIONIC ACID FROM MIXTURE OF ITS ALKYL ESTER ENANTIOMERS Russian patent published in 1999 - IPC

FIELD: organic chemistry, biotechnology. SUBSTANCE: method is based on the use of biocatalyst. Microorganism of genus Ophiostoma or a substance eliciting an enzymatic activity on its basis is used as a stereospecific agent in reaction of bioconversion to produce (S)-ketoprofen from a mixture of enantiomers of its alkyl ester. Microorganism Ophiostoma novo-ulmi IMI 356050 is used preferably. Reaction is carried out at pH 8-11 but preferably - at 9.5-10.5. EFFECT: increased yield of an enantiomeric excess of the end product. 6 cl, 7 tbl, 6 ex