CYCLIC INHIBITORS OF ADHESION Russian patent published in 1998 - IPC

FIELD: chemistry of peptides. SUBSTANCE: composition has cyclopeptide taken from the following groups: cyclo-(-Arg-Gly-Asp-D-Phe-Val-Ala); cyclo-(-Arg-Gly-Asp-D-Phe-Leu-Ala); cyclo-(-Arg-Gly-Asp-Phe-Val-D-Ala); cyclo-(-Arg-Gly-Asp-Phe-Leu-D-Ala); cyclo-(-Arg-Gly-Asp-D-Phe-Val-Gly); cyclo-(-Arg-Gly-Asp-D-Phe-Leu-Gly); cyclo-(-D-Arg-Gly-Asp-Phe-Val-Ala); cyclo-(-D-Arg-Gly-Asp-Phe-Val-Gly); cyclo-(-Arg-Gly-Asp-Phe-Pro-Gly); cyclo-(-Arg-Gly-Asp-Phe-D-Pro-Gly); cyclo-(-Arg-Gly-Asp-Phe-Pro-Ala); cyclo-(-Arg-Gly-Asp-Phe-D-Pro-Ala); cyclo-(-D-Arg-Gly-Asp-Phe-Val); cyclo-(-Arg-Gly-Asp-D-Phe-Val); cyclo-(-Arg-Ala-Asp-D-Phe-Val); cyclo-(-Arg-Gly-Asp-Phe-D-Val); cyclo-(-Arg-Gly-D-Asp-Phe-Val) or its salt. Indicated composition can be used in medicine for treatment and prophylaxis of thrombosis, myocardium infarction, hemorrhage, arteriosclerosis, inflammation, stenocardia and/or tumors, osteoporosis. EFFECT: enhanced effectiveness of composition. 6 cl, 7 ex, 1 tbl