FIELD: applied virology. SUBSTANCE: invention relates to methods of isolation, purification and modification of viruses and viral preparations i. e. to processes associated with virus concentrating. Method involves virus binding with bioaffinity sorbent containing antibodies raised to virus and immobilized on polymer base, washing out and desorption. Polymer base of bioaffinity sorbent is cryogel of polyvinyl alcohol (pore size is 0.04-2.0 mcm). Also, bioaffinity sorbent can contain both immobilized enzymes modifying virus and antibodies. Proposed method shows the following advantages as compared with analogs and prototype: a) enhanced effectiveness of method; b) increased universality. Invention can be used both in scientific investigations and in production of vaccines and diagnostics and in medicine practice also. EFFECT: improved method of virus concentrating. 2 cl, 7 ex
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