ANTITUMOR NANOPARTICLES WITH MODIFIED SURFACE AND COMPOSITION CONTAINING THEREOF Russian patent published in 1999 - IPC

FIELD: pharmacology. SUBSTANCE: particles being dispersed consist of crystalline antitumor substances. Surface modifier is adsorbed on particle surface in amount 0.1 to 90 wt % that is high enough to retain average effective particle size below 1000 nm. Surface modifier represents polyvinyl alcohol, tetrafunctional block copolymer resulting from successive addition of ethylene oxide and propylene oxide to ethylenediamine, gum Arabic, ethylene oxide/propylene oxide block copolymer, fatty acid ester with polyoxyethylenesorbitan, and fatty acid ester with sorbitan. EFFECT: reduced toxicity and/or increased activity, and enabled intravenous administration. 16 cl, 23 ex