PROCESS FOR PREPARING INDOLE DERIVATIVES Russian patent published in 1999 - IPC

FIELD: chemical industry. SUBSTANCE: present invention describes indole derivatives of general formula I wherein E is straight or branched C₁-C₄-alkylene chain: R is group of formula: -CH₂-CHR¹-NR²R³ wherein R¹ is hydrogen; R² and R³ are identical and are C₁-C₆-alkyl. The claimed process comprises reacting 4-amino-1,2,4-triazole with nitrobenzene derivative containing readily replaceable group, deaminating the thus obtained aminotriazolium salt by treatment with nitrogenous acid followed by neutralization, reducing the thus obtained triazolinyl- nitrobenzene derivative by transfer hydrogenation, treating the thus obtained triazolyl-aniline derivative with nitrogenous acid and then with alkali metal sulfate followed by acidification, and the thus obtained triazolyl-hydrazine derivative is then reacted in reaction medium with suitable carbonyl compound of formula: wherein Alk is methyl. The desired compound with yield of 96% is obtained without isolation of intermediate compounds. EFFECT: more efficient preparation process. 10 cl, 2 ex