DERIVATIVES OF ARYLSULPHONYLSTILBENE FOR TREATMENT OF INSOMNIA AND ASSOCIATED WITH IT DISORDERS Russian patent published in 2010 - IPC C07C317/44 C07D205/04 C07D207/10 C07D211/38 C07D213/71 C07D233/64 C07D241/08 C07D249/08 C07D271/10 C07D295/96 A61K31/10 A61K31/235 A61K31/4164 A61K31/4245 A61P25/18 

Abstract RU 2382766 C2

FIELD: medicine.

SUBSTANCE: invention relates to novel compounds of formula or to its pharmaceutically acceptable salts, where n is 0 or 1; R1 represents H or F; R2 represents C1-4alkyl; R7 represents H or C1-4alkyl; and Z represents hydroxyl C1-6alkyl or C1-6alkoxycarbonyl, or 5- or 6-member heteroaromatic ring, which belongs to aromatic rings which have given number of atoms, of which at least one is N, O or S, the remaining being carbon atoms, and which also optionally has methyl substituting group. Invention also relates to pharmaceutical composition, to application of compounds, as well as to method of obtaining formula I compounds.

EFFECT: obtaining novel biologically active compounds, possessing activity of receptor 5-HT2A antagonists.

9 cl, 25 ex

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RU 2 382 766 C2

Authors

Dzhilligan Mira

Khamfriz Aleksandr Charl'Z

Khant Piter Alan

Ladduvakhetti Tamara

Makleod Angus Mjurrej

Merchant Kevin Dzhon

Dates

2010-02-27Published

2005-08-26Filed