MODIFIED OLIGODEOXYRIBONUCLEOTIDES, COMPOSITION BASED ON THEREOF AND INTERMEDIATE COMPOUNDS Russian patent published in 1998 - IPC

Abstract RU 2111971 C1

FIELD: organic chemistry, chemistry of nucleic acids. SUBSTANCE: invention relates to derivatives of oligodeoxyribonucleotides of the general formula (I) where R1, R2 and R3 mean hydrogen atoms, alkyl groups, aryl groups given in description and anthraquinonylic group given in description; Z means carbon or silicon; or R2, R3 and Z together form fluorenyl or xanthenyl; R4 means hydrogen atom, alkyl group as given in description, aryl group given in description; Y1, Y3 and Y4 mean oxygen, sulfur or group ; Y2 means oxygen, sulfur, , alkylene or phenylene; X - alkylene group as given in description; m and n mean 0-10, and B - oligodeoxyribonucleotide (its chain length is 3-9), or their salts. Proposed compounds can be used for prophylaxis and treatment of viral infections in mammalian. EFFECT: improved method of synthesis. 10 cl, 4 tbl

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RU 2 111 971 C1

Authors

Khidekhiko Furukava[Jp]

Kendzi Momota[Jp]

Khitosi Khotoda[Jp]

Makoto Kojzumi[Jp]

Masakatsu Kaneko[Jp]

Dates

1998-05-27Published

1994-01-28Filed