FIELD: medicine. SUBSTANCE: described are new intermediate products of camptotecine of formula I: 
wherein Ra is chlorine atom, lower alkoxy group, Rb is hydrogen atoms, C1-8 alkyl, hydroxy C1-8 alkyl, C(O)H or group(a); Rc is group selected from formula II-IX, or Rb and Rc together form residue of formula 
or 
is chlorine atom or group C(O)OR4; R3 is hydrogen atom or benzyl; R4 is C1-8 alkyl; R5 is hydrogen atom; R6 is C1-8 alkyl; R7 is hydrogen atom. Compounds are active anticancer medicinals. Also described is method of preparing camptotecine (CPT-11) derivatives and related compounds. EFFECT: improved properties of the title compounds. 87 cl, 4 dwg
| Title | Year | Author | Number |
|---|---|---|---|
| 14-SUBSTITUTED MARCFORTINES | 1994 |
|
RU2131877C1 |
| RING-SUBSTITUTED PHENYLOXAZOLIDINONES WITH HETEROAROMATIC RINGS AS ANTIBACTERIAL AGENTS | 1996 |
|
RU2154645C2 |
| ANTIPARASITIC MARCFORTINES AND PARAHERCVAMIDES | 1996 |
|
RU2162090C2 |
| OXAZOLIDINONE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS BASED ON THEREOF | 1998 |
|
RU2215740C2 |
| METHOD OF OBTAINING ARYL ETHERS | 2005 |
|
RU2330012C2 |
| TROPONE-SUBSTITUTED PHENYLOXAZOLIDINONE OR ITS PHARMACEUTICALLY ACCEPTABLE SALTS OR HYDRATES | 1993 |
|
RU2119484C1 |
| METHOD FOR PREPARING 7-SUBSTITUTED STEROID COMPOUNDS, COMPOUNDS, METHODS FOR PREPARING EPLERENON, PRODUCT | 2003 |
|
RU2289586C2 |
| PHENYLOXAZOLIDINONES HAVING C-C-BOND WITH 4-8-MEMBERED HETEROCYCLIC RINGS | 1996 |
|
RU2175324C2 |
| AZAANTRACYCLINE DERIVATIVES AND PHARMACEUTICAL COMPOSITION | 1996 |
|
RU2159245C2 |
| SUBSTITUTED PYRIMIDINETHIOALKYL OR ALKYLESTER COMPOUNDS AND METHOD OF INHIBITION OF VIRAL REVERSE TRANSCRIPTASE ACTIVITY | 1996 |
|
RU2167155C2 |
