FIELD: biotechnology, immunology, virology.
SUBSTANCE: invention relates to CR3 chimera gene having sequence of SEQ ID NO:1 encoding chimera polyprotein. Said gene contains fragments, encoding fragments enriched with cyrotoxic T-cell epitope (CTL). Such fragments are selected from internal conserved and regulatory proteins, HIV epitopes of T-helper cells (Th), and B-cell epitope. Chimera polyprotein contains fragments of various HIV proteins inducing anti-HIV-1 immune response.
EFFECT: invention useful in HIV treatment and prevention.
7 cl, 10 dwg, 2 tbl, 11 ex
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