FIELD: medicine. SUBSTANCE: camptotecin derivatives of general formula I wherein 
is hydrogen or R1 alkyl group; C1-6 is hydrogen or R2 alkoxy group; C1-6 is hydrogen or halogen, R3 alkyl, C1-6 alkoxy, hydroxyl, C1-6 acyloxy or methoxyethoxy methoxy group; C2-6 is hydrogen or halogen, and R4 is R5 alkyl, C1-6 unsaturated alkyl, alkylthioalkyl, alkoxyalkyl, pyridyl or substituted phenyl group provided that all C3-C6 substituents should not be hydrogen atoms. Said compounds have superior antitumor activity. EFFECT: improved properties of the antitumor composition. 4 cl, 4 ex, 6 tbl R2, R3 and R4
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