FIELD: medicine. SUBSTANCE: antithrombotic peptides of formula I: -NE-CHF-(CO)r-G wherein A and R hydrogen, B is alkyl; Z is OR1; E is hydrogen; F is hydrogen, alkyl, hydroxyalkyl, cycloalkyl, cycloalkylalkyl, aralkyl or substituted aralkyl; G is cycloalkylalkyl, NR1R2, or R1 and R2, 
are hydrogen or alkyl, r is 0 or 1, m is 1-5, n is 0-6 and p is 1-4, or pharmaceutically acceptable salts thereof are useful prophylaxis and treatment of thrombosis. EFFECT: properties of the title compounds. 14 cl, 34 ex, 1 tbl
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