DERIVATIVES OF 3-H-1,2,3-TRIAZOLO-[4,5-D]-PYRIMIDINE, PHARMACEUTICAL COMPOSITION AND METHOD OF THEIR SYNTHESIS Russian patent published in 2001 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to derivatives of 3-H-1,2,3-triazolo-[4,5-d] -pyrimidine of the general formula (I) where B means O or CH₂; X is taken among NR¹R²,SR¹ and C₁-C₇-alkyl; Y is taken among SR¹,NR¹R² and C₁-C₇-alkyl; R¹ and R² each means independently H or C₁-C₇-alkyl; or R¹ means C₁-C₇-alkyl optionally substituted in alkyl chain with O or S or one or more halogen atoms and R² means hydrogen atom; R³ and R⁴ both mean hydrogen atom or in common they form bons; A means COOH, C(O)NH-(CH)_p-COOH, C(O)N[(CH₂)_q-COOH]₂, C(O)NHCH-(COOH)-(CH₂)_r-COOH or 5-tetrazolyl where p, q and r each = 1, 2 or 3 independently and also their pharmaceutically acceptable salts or esters. Invention describes also method of synthesis of these compounds and pharmaceutical composition containing thereof. Claimed compounds prevent platelet aggregation. EFFECT: improved method of synthesis, valuable medicinal properties. 17 cl, 26 ex