PYRAZOLO- AND PYRROLOPYRIDINES Russian patent published in 1999 - IPC

Abstract RU 2135498 C1

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to the compound of the formula (I) and pharmaceutically acceptable acid-additive salts where A means N or CH; B means -NT₁R₂,-NHCHR₁R₂,-OCHR₁R₂. Compounds show an antagonistic activity with respect to corticotropin-releasing factor (CRF). It is known that CRF-antagonists are effective for treatment of broad spectrum of diseases caused by stress, for example, depression, fear, headache, irritable bowel syndrome, inflammatory diseases, immunity attenuation, Alzheimer's disease, gastroenteric diseases, neurotic anorexia, hemorrhagic stress, abstinent syndrome of drug and alcohol withdrawal, addiction to excess use of drugs and sterility. EFFECT: enhanced effectiveness of compounds. 7 cl, 1 tbl, 8 ex

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RU 2 135 498 C1

Authors

Jufing L.Chen

Dates

1999-08-27—Published

1995-05-18—Filed