FIELD: medicine, immunology, virology. SUBSTANCE: for immunization the living recombinant vaccine against tick-borne encephalitis based on smallpox vaccine is used. Vaccine is prepared on the basis of the strain KV 7,5 CMENS 123 (strain GKV N 945) or the strain WR 7,5 CMENS 123. Using pipet or special syringe vaccine is administrated in body by intranasal route in the region of nose mucosa olfactory neuroepithelium at the dose (0.5-5.0) x 106 OOE. The most optimal dose of the preparation is 106 OOE at volume 50 mcl. Invention provides the specific immunoprophylaxis against tick-borne encephalitis, in part, protection of brain against tick-borne encephalitis virus by parenteral infection due to formation of local immunity of nasal cavity mucosa, decrease loading on systemic immunity and decrease the dose of the preparation administrated in body being without damage of skin. EFFECT: enhanced effectiveness of immunization, simplified procedure. 2 cl, 3 tbl, 4 ex
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| RECOMBINANT PLASMID DNA PC-NS3 PROVIDING INTEGRATION OF COMPLEX OF GENES C, PRM, E, NS1, NS 2A, NS 2B, NS3 OF TICK-BORNE ENCEPHALITIS VIRUS IN GENOME OF BOVINE VACCINE VIRUS AND RECOMBINANT STRAIN OF BOVINE VACCINE VIRUS EXPRESSING COMPLEX OF GENES C, PRM, E, NS1, NS 2A, NS2B, NS3 OF TICK-BORNE ENCEPHALITIS VIRUS IN IMMUNIZED ORGANISM CELLS |
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2001 |
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2016 |
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| KIT OF TABLETTED ALIVE RECOMBINANT ORAL BIVACCINE AGAINST SMALLPOX AND HEPATITIS B AND METHOD FOR VACCINATION AT APPLYING THE KIT MENTIONED |
2005 |
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| LIVE ATTENUATED CULTURE VACCINE FOR PREVENTION OF SMALLPOX AND OTHER ORTHOPOXVIRUS INFECTIONS BASED ON SMALLPOX VACCINE VIRUS AND METHODS FOR ITS PREPARATION AND APPLICATION |
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| VACCINE AGAINST VIRAL INFECTIONS |
2000 |
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| TABLETED LIVE RECOMBINANT BIVACCINE "REVAKS VKT" AGAINST NATURAL SMALLPOX AND HEPATITIS B AND METHOD FOR ITS PREPARING |
2002 |
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RU2133625C1 |
| VIRAL GENOME FRAGMENT OF CHICKEN K STRAIN VARIOLA WHICH CONTAINS THYMIDINE KINASE GENE, pTK1FPV AND pTK2FPV RECOMBINANT PLASMID DNAs WHICH CONTAIN THIS SEQUENCE, AND pINTFPV1 RECOMBINANT PLASMID DNA WHICH IS ABLE TO INTEGRATE INTO VIRAL GENOME OF CHICKEN VARIOLA |
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