METHOD OF PREPARING 9-AMINOCAMPTOTECINE AND SULFONYLOXY-DERIVATIVES OF 9-NITRO-20(S)- CAMPTOTECINE Russian patent published in 1999 - IPC

FIELD: organic synthesis. SUBSTANCE: 9- aminocamptotecine with formula I (presented in description) is prepared by reaction of compound depicted by formula III, wherein hydroxy group of ring A is located in position 10 or 12, with nitration agent to form corresponding compound IV. The latter is further converted into compound V in which XO is a group replaceable upon hydrogenation. Next step of reaction consists in reductive removal of group XO and simultaneous reduction of nitro group in compound V to give final product (I). Compounds of formulas V and VII exhibit antitumor activity. EFFECT: simplified process and reduced expenses. 15 cl, 21 ex