METHOD OF PREPARING 9-AMINOCAPTOTHECIN, INTERMEDIATE PRODUCTS, AND METHOD OF PREPARING THEREOF Russian patent published in 2000 - IPC

Abstract RU 2145325 C1

FIELD: chemical industry. SUBSTANCE: 9-aminocaptothecin of formula I: is prepared by reacting reduced compound of formula II with diazotizing agent to form compound of formula IV which successively nitrated and nitro group is reduced, and halogen is simultaneously removed in compound of formula V: . Method makes it possible to recycle 12-nitroderivative into process by means of conversion of 9-amino under simple and mild conditions to attain high yields and purity of the reaction products. EFFECT: more efficient preparation method. 11 cl, 12 ex

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RU 2 145 325 C1

Authors

Andzhelo Bedeski

Val'Ter Kabri

Ilaria Kandiani

Franko Zarini

Dates

2000-02-10—Published

1994-07-18—Filed