AMIDINO-DERIVATIVES, THEIR USE AND PHARMACEUTICAL COMPOSITION Russian patent published in 1999 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to amidino-derivatives of the general formula (I) and their salts, pharmaceutically acceptable esters and prodrugs also where X - methylene; n = 1-7; R¹, R² - hydrogen atom, alkyl, alkenyl, alkynyl, amino-group, carboxylic group, halogenalkyl, C_3-6-alicyclic hydrocarbon, C_4-10-aromatic hydrocarbon being indicated radicals can be substituted with 1 or some substituents taken among hydroxyl, alkyl, alkoxyl, amino, carboxyl, carboalkoxy-group which in turn can be substituted with amino- or carboxyl-group or substituents R¹ and R² in common can form optionally C_3-6-alicyclic hydrocarbon; R³, R⁴ - H or OH. Compounds of the formula (I) can be used as inhibitors of NO-synthetase. EFFECT: valuable pharmacological and biochemical properties. 12 cl, 2 tbl, 328 ex