SULFONYLALKANOYLAMINO-HYDROXYETHYLAMINO-SULFONAMIDE COMPOUND, PHARMACEUTICAL COMPOSITIONS AND METHODS OF TREATMENT AND INHIBITION OF RETROVIRAL PROTEASES Russian patent published in 2000 - IPC

FIELD: organic chemistry, virology, pharmacy. SUBSTANCE: invention describes the novel compound - sulfonylalkanoylamino-hydroxyethylamino-sulfonamide compound of the general formula (I) where R means alkyl; R¹, R²⁰, R²¹ mean independently hydrogen atom or alkyl; R² means alkyl or aralkyl; R³ means alkyl; R⁴ means aryl that is optionally substituted with one or some substituents taken among the group involving alkyl, alkoxy-, hydroxy-, amino-, acetamino-group; or benzothiazole, benzodioxyolyl, benzofuryl, benzimidazolyl, benzodioxanyl; R⁶ means hydrogen atom; Y means oxygen atom; x = 2; t = 0 or 1, or its pharmaceutically acceptable salts. Compounds are effective antiviral agents, especially, against retroviral infections. In part, they are effective inhibitors of HIV-infection and can inhibit other retroviruses, for example, lentiviruses, other HIV-virus strains, leukemia virus of human T-cells and so on. EFFECT: enhanced antiviral activity of compounds. 34 cl, 11 tbl, 24 ex