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IPC

(21) (22)

Application

97112593/13, 1997-07-23

(24)

Start date

1997-07-23

(22)

Actual filing date

1997-07-23

(45)

Published

1999-12-10

(72)

Inventor

Pikalova M.I.Domanova Z.M.Khajbullina I.I.Enikeeva R.V.Naumova N.V.Kolokol'Tsov A.A.

(73)

Holder

Gosudarstvennyj Nauchnyj Tsentr Virusologii I Biotekhnologii

METHOD OF INDUSTRIAL PRODUCING POLYPEPTIDE SHOWING BIOLOGICAL ACTIVITY OF HUMAN LEUKOCYTE INTERFERON ALPHA-2 Russian patent published in 1999 - IPC

Abstract RU 2142508 C1

FIELD: biotechnology, polypeptides. SUBSTANCE: recombinant bacterial cells Pseudomonas species VG-84 are cultured on the nutrient medium containing glucose (25-60 g/l), streptomycin and tetracycline. Culturing is carried out under aeration conditions. Culturing can be performed at the batch feeding the nutrient medium containing glucose (80 g/l). Invention can be used for the industrial large-scale production of human recombinant interferon. EFFECT: increased yield of the human recombinant interferon alpha-2. 2 cl, 3 tbl, 3 dwg, 2 ex

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RU 2 142 508 C1

Authors

Pikalova M.I.

Domanova Z.M.

Khajbullina I.I.

Enikeeva R.V.

Naumova N.V.

Kolokol'Tsov A.A.

Dates

1999-12-10—Published

1997-07-23—Filed