FIELD: immunology, biotechnology. SUBSTANCE: monoclonal antibody to rapamycin that is able to recognize epitope on FKBP-binding domain or on effector domain of rapamycin or monoclonal antibody to 40-O-(2-hydroxyethyl)-rapamycin is prepared using immunogenic conjugate containing 40- O-succinimidooxysuccinyl-rapamycin or 28-O-succinimidooxysuccinyl-rapamycin, or 28-O- (succinimidooxysuccinyl)-40-O-(2-hydroxyethyl)-rapamycin and immunogenic protein. Invention ensures to develop the test-system for immunosuppressive derivatives of rapamycin and for rapamycin testing. EFFECT: improved method of testing, monoclonal antibody indicated above. 12 cl, 11 dwg, 6 ex
