METHOD OF LYOPHILIZED LIPOSOME PREPARING Russian patent published in 2000 - IPC

Abstract RU 2144352 C1

FIELD: medicine, pharmacy. SUBSTANCE: invention relates to lyophilized liposomes used for preparing preparations for intravenous administration. Method involves dissolving substances that are able to form lipid vesicles in organic solvent, drying solution to obtain film, resuspending lipid film in dispersion medium in the presence of cryprotecting agent, dispersing lipid suspension to obtain microemulsion, freezing microemulsion and the following lyophilization. Microemulsion is frozen at (-35)-(-45) C and before lyophilization the frozen emulsion is hardened at (-50)-(-60) C. Lecithin, cholesterol, mixture of acid phospholipids isolated from soybean phosphatides as the single component and possibly DL-α-tocopherol are used as substances that are able to form vesicles. Drug aqueous solution can be used as dispersion medium and sucrose is used as cryprotecting agent. EFFECT: prolonged storage time of liposomes, easily resuspensability. 5 cl, 1 tbl, 3 ex

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RU 2 144 352 C1

Authors

Shanskaja A.I.

Ivanova R.P.

Bulusheva E.V.

Jakovleva T.E.

Militsina T.V.

Dates

2000-01-20—Published

1997-07-16—Filed