FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to pharmacology and represents a dried pharmaceutical composition containing a lyophilised active agent containing vesicles comprising: a) at least one lipid, b) at least one active agent which appears to be protein or its active fragment, c) a fusion promoting agent, where the fusion promoting agent is an alkaline amino acid selected from arginine, histidine, lysine or citrulline, and d) being free from a membrane stabilising agent, where rehydration of the dried pharmaceutical composition with using an aqueous solution causes formation of multilamellar liposomes having an average liposome diameter exceeding 1 mcm with these liposomes encapsulating the active agent.
EFFECT: invention provides high efficacy and stability of the active agent in the liposomes having the diameter exceeding 1 mcm.
28 cl, 9 ex, 2 tbl, 3 dwg
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